Kharlampieva Research Group


    Department of Chemistry, University of Alabama at Birmingham
    901 14th Street South CHEM291, Birmingham, AL 35294

Research Projects  
Our research was featured in the following journals:  


We show nanothin temperature-responsive hydrogel films of poly(N-vinylcaprolactam) nanoparticles (νPVCL) loaded with a non-steroidal anti-inflammatory drug used for osteoarthritis pain management can provide sustained permeation of the drug through an artificial skin for 24 h at the average human skin temperature. J. Colloid Interface Sci. 2017, 506, 589.
This review summarizes a pool of current experimental approaches and discuss perspectives in the development of the synergistic combination of shape and stimuli-response in particulate hydrogels.  The paper discusses the effects of shape on the physiochemical properties of the particles and their shape-regulated biological interactions. J. Mater. Chem. B, 2017, 5, 9.
This Perspective highlights recent developments in the field of polymer particulates such as solid particles, micelles, hydrogels, and templated multilayer systems that undergo shape changes under various stimuli. The fundamental issues related to the design and shape-adaptable properties of both spherical and nonspherical particles are discussed as well as their prospective applications in controlled drug delivery. Macromolecules 2016, 49(22), 8373.
Spherical and cubical microcapsules were made via layer-by-layer assembly of hydrogen-bonded tannic acid/poly(N-vinylpyrrolidone)
(TA/PVPON) as hollow polymer shells. Cubical geometry promotes more efficient interaction of capsules with breast cancer cells, while elasticity prevents engulfment by phagocytic cells in the tumor microenvironment. Adv. Healthcare Mater. 2015, 4, 2657.
Nanoconfinement is a way to create materials whose properties differ from the bulk. For the first time, this research explores the effect of nanoconfinement on the thermodynamics and kinetics of gel melting. Physical Chemistry Chemical Physics, 2016, 18, 29056.
Hydrogen-bonded multilayers of natural polyphenol efficiently dissipate
pro-inflammatory reactive oxygen and nitrogen species
and attenuate the production of pro-inflammatory cytokines, which may provide physical pancreatic islet transplant protection and
prevent diabetogenic autoreactive T-cell responses in Type 1 diabetes patients. Adv. Healthcare Mater. 2015, 4, 686.
This work describes hydrogen-bonded multilayer capsules of tannic acid that are used for highly efficient encapsulation of anticancer drug doxorubicin and its storage in the pH range 5 < pH < 7.5. These ultrathin capsules are developed for targeted intracellular drug delivery for cancer therapy. Soft Matter, 2014, 10, 9237.
Novel cubical microgels for pH-triggered delivery of anticancer drugs were developed by replicating mesoporous inorganic templates. This approach provides a new platform for synthesis of multi-functional particles with highly-controlled geometry, composition, and properties to be used in targeted drug delivery for cancer therapy J. Mater. Chem. B, 2014, 2, 2494.
Our Group in the news:
- NSF News From the Field (Jan, 30, 2018)
- Microcapsules gain a new power - scavenging reactive oxygen species (UAB News, Jan, 30, 2018)
- Active drug-delivery system addresses the limitations seen for the anti-cancer drug BA-TPQ - poor solubility and low bioavailability (Eurekalert! American Association for the Advancement of Science, June, 28, 2017)
- Micron-sized hydrogel cubes show highly efficient delivery of a potent anticancer drug (UAB News, June 28, 2017)
- UAB creates triple-threat cancer-fighting polymer capsules for guided drud delivery (UAB News, March 30, 2017 and
the NSF news)
- Dr. Kharlampieva's interview on the ACS Polymer Science monthly podcast series on shape-adaptable polymeric particles for controlled delivery (ACS Publications, Dec, 2016)
- Detecting pollutants in Gulf Coast marine ecosystems (UAB News, Dec 6, 2016)
- Stealth pig cells may hold the key to treating diabetes in humans (UAB News, Sept 7, 2016)
- Changes in shape and 'squishiness' can help drug-containing microcapsules reach tumors (UAB News, Feb 12, 2016)
- Attacking cancer with tiny, squishy balls and cubes (UAB News, Feb 11, 2016)
- Our work on cubical multilayer capsules was featured by Federation of American Societies for Experimental Biology (FASEB) (Dec, 2015)
- Kharlampieva Named President of UAB Sigma Xi Chapter (UAB News, Oct, 21, 2015)
- Kharlampieva focuses on shape-shifting research for drug delivery (UAB Reporter, April, 10, 2014)
- Curing diabetes, with a little help from polymer science: coating could make widespread treatment a reality (Materials Views, May 18, 2012)
- New coating for pancreatic islets may offer new hope for diabetics (UAB News, May 31, 2012)
- Promise of novel drug-delivery systems that can invade tumors to be explored (UAB Reporter, March 16, 2012)  
- UAB experts work on oil-spill recovery, disaster prevention (UAB News, April 20, 2012)  
- Small World: UAB Researchers Build the Nanoscale Future (UAB Magazine, October 2011)  

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